Biomedical Sensors and Instruments

IOS researchers have developed cutting-edge technologies, including fiber optic sensors for pressure, temperature, electromagnetic fields, and a wide variety of chemicals; acoustic emission sensors; advanced signal and image processing systems; specialty light sources; non-lethal weapons; and non-destructive visual and laser ultrasonic inspection systems.

IOS has demonstrated the feasibility of incorporating a promising new type of microfluidic device into blood assay kits on a micro scale in a “biochip” format. The innovative microfluidic device is based on electrowetting-on-dielectric (EWOD) technology, and has potential to reduce fabrication costs, simplify operation, and lower sample volumes for a wide range of analytical targets.

Addressing the need for an off-the-shelf, online, in situ system that detects biofilms, IOS developed a portable monitoring system for screening bacterial fouling in dental unit water delivery lines and other medical fluid delivery systems. This innovative device operates by detecting the autofluorescence of characteristic biofilm markers.

Microwave hyperthermia has been clinically proven to be an effective, efficient and non-toxic alternative to surgical procedures for removing or reducing tumors. Unfortunately, its use has been limited by the lack of an effective tool to monitor, and thereby control, the heat distribution during microwave treatment of tumors. Applying its expertise in this area, IOS produced an advanced distributed optical fiber temperature (OFT) sensor to accurately monitor temperatures for hyperthermia tumor treatment. The OFT probe collects ten points of high-resolution temperature data in a single fiber, an efficient alternative to the thick bundles of arrayed single point temperature probes and expensive MRI thermometry that are otherwise required for distributed temperature monitoring in tissue.